Name: Spinorphin

CAS No.: 137201-62-8

Sequence: Leu-Val-Val-Tyr-Pro-Trp-Thr

Molecular formula: C45H64N8O10

Molecular weight: 877.03

Quantity in stock : 10 grams

Purity: >98.0%

Packing : According to clients’ requirements

Source : synthetic

Shipping: Global Delivery

Spinorphin is an endogenous, non-classical opioid peptide of the hemorphin family first isolated from the bovine spinal cord (hence the prefix spin-) and acts as a regulator of the enkephalinases, a class of enzymes that break down endogenous the enkephalin peptides.It does so by inhibiting the enzymes aminopeptidase N (APN), dipeptidyl peptidase III (DPP3), angiotensin-converting enzyme (ACE), and neutral endopeptidase (NEP).It has been observed to possess antinociceptive, antiallodynic, and anti-inflammatory properties. The mechanism of action of spinorphin has not been fully elucidated (i.e., how it acts to inhibit the enkephalinases), but it has been found to act as an antagonist of the P2X3 receptor, and as a weak partial agonist/antagonist of the FP1 receptor.

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